| Rt Hon Alun Edward Michael | 13 May 1999 | 9 February 2000 |
| Hywel Rhodri Morgan | 9 February 2000 | 9 December 2009 |
| Carwyn Howell Jones | 9 December 2009 | 12 December 2018 |
| Prof Mark Drakeford | 13 December 2018 | 20 March 2024 |
| Vaughan Gething | 20 March 2024 | 24 July 2024 |
| Mair Eluned Morgan, Baroness Morgan of Ely | 24 July 2024 | 8 May 2026 |